Van Gieson (VG) Staining Kit

Collagen fibers are the most widely distributed and abundant fibers in connective tissue, found extensively in various organs, especially in the skin, sclera, and tendons. Type I collagen fibers are mainly found in bone, skin, and tendons; Type II collagen fibers are primarily found in cartilage; Type III collagen fibers are mainly present in embryonic tissues and adult blood vessels and gastrointestinal tract; Type IV collagen fibers are mainly found in the basement membrane.The principle of Van Gieson collagen fiber staining is related to the size of anionic dye molecules and tissue permeability. Molecular size is reflected by molecular weight: smaller molecules penetrate dense, low-permeability tissues more easily, while larger molecules can only enter loose, high-permeability tissues. Phosphomolybdic acid (PA) has the smallest molecular weight, followed by acid fuchsin and ponceau, while light green has the largest. After VG staining, muscle fibers appear yellow, and collagen fibers appear red.EnkiLife Van Gieson (VG) Staining Solution is commonly used to distinguish collagen fibers from muscle fibers, to differentiate collagen-derived tumors from muscle-derived tumors, and to observe tissue or organ damage, repair, and fibrosis. Storage: store at RT for 12 months For more information, you can visit the product URL: https://www.enkilife.com/p/Van-Gieson-VG-Staining-Kit-RA20134